Supervised learning, such as regression and classification, is an essential tool for analyzing modern high-throughput sequencing data, for example in microbiome research.However, due to the compositionality and sparsity, existing techniques are often inadequate.Either they rely on extensions of the linear log-contrast model (which adjust for compos
Mapping of mitral regurgitant defects by cardiovascular magnetic resonance in moderate or severe mitral regurgitation secondary to mitral valve prolapse
Abstract Purpose In mitral valve prolapse, determining whether the valve is suitable for surgical repair depends on the location and mechanism of regurgitation.We assessed whether Air Fryers cardiovascular magnetic resonance (CMR) could accurately identify prolapsing or flail mitral valve leaflets and regurgitant jet direction in patients with know
Childhood langerhans cell histiocytosis: A bizarre thoracic-spine presentation of a multi-organ disease and a narrative review of the literature
Langerhans cell histiocytosis is a rare disease with diverse clinical presentations.We report a 4-year-old boy with progressive weakness in lower extremities, a large head lump, and inability to walk.On physical examination, bulged scalp, ulcerative skin lesions, engorged veins over the abdomen and chest, and decreased muscle strength were evident.
Synthesis and characterization of actively HER-2 Targeted Fe3O4@Au nanoparticles for molecular radiosensitization of breast cancer
Introduction: The present study was done to assess the effect of molecularly-targeted core/shell of iron oxide/gold nanoparticles (Fe3O4@AuNPs) on tumor radiosensitization of SKBr-3 breast cancer cells.Methods: Human epidermal growth factor receptor-2 (HER-2)-targeted Fe3O4@AuNPs were synthesized by conjugating trastuzumab (TZ, Herceptin) to PEGyla